From there, the projections leave the hippocampus to return to the inferior temporal cortex, temporal pole, and prefrontal cortex. These pyramidal cell neurons are further divided into two branches: one branch reaches the opposite side of the hippocampus via corpus callosum the other branch connects to CA1 through Schaffer collateral pathways. Form there, neurons of the dentate gyrus send mossy fibers to the neurons of pyramidal cells located in CA3. In the polysynaptic pathway, hippocampus receives afferent inputs via axons of the entorhinal cortex, which terminate in the dentate gyrus. The complex processes of memory encoding in the hippocampus and retrieval of experiences from the frontal lobe involve two prominent pathways: polysynaptic and direct pathways. Long-term potentiation (LTP), which is a form of neural plasticity, occurs in the hippocampus, and LPT is a vital brain mechanism involved in memory storage. These regions form the trilaminar loop, which is the processing center of long-term memory. Hippocampus is divided into three regions: CA1, CA2, and CA3. Being an integral part of the limbic system, hippocampus plays a vital role in regulating learning, memory encoding, memory consolidation, and spatial navigation.
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